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Excess melanocytic nevi in children with renal allografts
C H Smith1, J M McGregor, J N Barker
1Department of Dermatology, Guy's Hospital, London, England.
Background:
Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk.
Objective:
This study determines the prevalence of melanocytic nevi in children who have received renal allografts.
Methods:
Total and regional melanocytic nevi counts were made in 38 children (27 boys, 11 girls) with a renal allograft and in 38 individually age- and sex-matched healthy controls; counts were related to age, sex, skin type, and duration of immunosuppression.
Results:
There was a significant increase in the total number of nevi in the renal transplant group compared with the control group (p < 0.05), with most marked increases occurring on the back and at acral sites. A strong positive correlation between nevi count and duration of immunosuppression independent of age was observed (p < 0.005).
Conclusion:
Excess numbers of melanocytic nevi occur in children with renal allografts. These patients constitute a risk group for malignant melanoma and require continued assessment.