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A radical proposal for the pathogenesis of scleroderma

D F Murrell1

  • 1Department of Dermatology, University of North Carolina, Chapel Hill.

Journal of the American Academy of Dermatology
|January 1, 1993
PubMed
Summary

Scleroderma lacks effective treatments due to unknown causes. This review proposes a free radical hypothesis and suggests testing antioxidants for scleroderma patients.

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Area of Science:

  • Immunology
  • Pathophysiology
  • Rheumatology

Background:

  • Scleroderma's etiology and pathogenesis remain largely speculative.
  • Current understanding does not provide effective therapeutic strategies for scleroderma and its variants.
  • This necessitates a review of existing concepts and the proposal of new hypotheses.

Purpose of the Study:

  • To review current concepts in scleroderma etiology and pathogenesis.
  • To propose a unifying hypothesis for scleroderma.
  • To suggest potential therapeutic avenues based on the proposed hypothesis.

Main Methods:

  • Literature review of existing research on scleroderma.
  • Analysis of current etiological and pathogenetic theories.
  • Formulation of a unifying hypothesis centered on free radical generation.

Main Results:

  • Current understanding of scleroderma's origins is limited.
  • A hypothesis implicating free radical generation in scleroderma pathogenesis is proposed.
  • The review highlights the need for further investigation into specific mechanisms.

Conclusions:

  • Free radical generation may play a significant role in scleroderma pathogenesis.
  • Testing free radical scavengers (antioxidants) in vitro and in clinical trials is warranted.
  • This approach may lead to novel therapeutic strategies for scleroderma.

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