Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human atherosclerotic plaque

T A Pearson, E C Kramer, K Solez

    The American Journal of Pathology
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
    Same author

    Acceptance of Gold Medal From the Catalan Society of Transplantation by Drs. Lorraine Racusen and Kim Solez - With Remarks on the Banff Meeting Spirit.

    Transplantation proceedings·2017
    Same author

    The bridge between transplantation and regenerative medicine: Beginning a new Banff classification of tissue engineering pathology.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
    Same author

    The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    PATHOLOGY OF CARDIOVASCULAR DISEASE.

    A listing of research in the cardiovascular field·2014
    Same author

    Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
    Same journal

    Lxrα Deficiency Primes Retinal Degeneration, but Aging Drives Disease Severity.

    The American journal of pathology·2026
    Same journal

    MYC is functionally required in both normal and neoplastic Meibomian glands.

    The American journal of pathology·2026
    Same journal

    Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis.

    The American journal of pathology·2026
    Same journal

    Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

    The American journal of pathology·2026
    Same journal

    APOE4 as a Modifier of Chemotherapy Response.

    The American journal of pathology·2026
    Same journal

    Spatial Pathobiology in the Omics Era: Transforming Modern Pathology.

    The American journal of pathology·2026
    See all related articles

    Atherosclerosis fibrous plaques may originate from a single altered smooth muscle cell, not just injury or clotting. This monoclonal origin is supported by glucose-6-phosphate dehydrogenase (G6PD) enzyme patterns in lesions.

    Area of Science:

    • Cardiovascular Biology
    • Cellular Biology
    • Pathology

    Background:

    • Atherosclerosis is characterized by fibrous plaques.
    • Current hypotheses suggest plaque formation results from mural thrombi or endothelial damage.
    • An alternative hypothesis proposes monoclonal proliferation of smooth muscle cells.

    Purpose of the Study:

    • To investigate the cellular origin of atherosclerosis fibrous plaques.
    • To test the hypothesis that plaques arise from monoclonal smooth muscle cell proliferation.

    Main Methods:

    • Analysis of glucose-6-phosphate dehydrogenase (G6PD) isoenzyme patterns in tissues.
    • Electrophoretic assays of G6PD isoenzymes in plaques and normal tissues.
    • Utilizing heterozygous females for X-linked G6PD as a cellular marker.

    Related Experiment Videos

    Main Results:

    • Normal tissues in heterozygous females showed both G6PD isoenzymes (A and B).
    • Atherosclerotic plaques predominantly exhibited a single G6PD isoenzyme.
    • Some fatty streaks also displayed a single G6PD isoenzyme pattern.

    Conclusions:

    • Findings support the monoclonal origin of fibrous plaques from altered smooth muscle cells.
    • This suggests a neoplastic-like process in atherosclerosis development.
    • Fatty streaks may represent an early stage in this monoclonal plaque development.