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A racial difference in erythrocyte sedimentation

R F Gillum1

  • 1Office of Analysis and Epidemiology, National Center for Health Statistics, Hyattsville, Maryland 20782.

Journal of the National Medical Association
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Blacks have a higher erythrocyte sedimentation rate (ESR) than whites, independent of age, hemoglobin, or certain diseases. This racial difference in ESR suggests distinct physiological factors may be at play.

Area of Science:

  • Clinical chemistry
  • Hematology
  • Public health

Background:

  • The erythrocyte sedimentation rate (ESR) is a common blood test used to detect inflammation.
  • Understanding demographic variations in ESR is crucial for accurate clinical interpretation.

Purpose of the Study:

  • To investigate potential racial differences in erythrocyte sedimentation rate (ESR) between Black and White populations.
  • To determine if observed ESR differences are influenced by age, hemoglobin levels, or specific chronic conditions.

Main Methods:

  • Analysis of data from the first National Health and Nutrition Examination Survey (NHANES I).
  • Comparison of median ESR values across different age and sex groups for Black and White participants.
  • Exclusion of individuals with extreme hemoglobin values or a history of conditions known to affect ESR.

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Main Results:

  • Black individuals exhibited higher median ESR values compared to White individuals across all age and sex strata (2-13 mm/hr higher).
  • Apparently healthy Black men and women were more likely to have elevated ESR levels than their White counterparts.
  • These disparities persisted even after controlling for hemoglobin concentration and certain chronic diseases.

Conclusions:

  • A significant racial difference in erythrocyte sedimentation rate (ESR) exists between Black and White populations.
  • This difference appears to be independent of age, hemoglobin concentration, and the presence of certain chronic diseases.
  • Further research is warranted to elucidate the underlying biological or environmental factors contributing to this observed racial disparity in ESR.