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Resolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis)
1Department of Radiology, Walter Reed Army Medical Center, Washington, DC 20307-5001.
Abstract:
Osmotic myelinolysis is a distinctive clinical syndrome with characteristic MR features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis). We describe the resolving MR features in an adolescent who has experienced complete neurologic recovery. Regions of involvement manifested increased T2 signal intensity. The extrapontine involvement was noted to resolve earlier with interim-increased T1-weighted signal. The mechanism for the variable appearance of increased T1 signal intensity is discussed.
Insights
Osmotic myelinolysis, a syndrome affecting the brainstem, shows distinct MRI changes. This case highlights the resolution of these magnetic resonance imaging features in an adolescent with full neurological recovery.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Osmotic myelinolysis is a neurological syndrome characterized by demyelination.
- It typically presents with specific magnetic resonance imaging (MRI) findings in the central pons (central pontine myelinolysis) and extrapontine regions.
- Complete neurological recovery is possible, though less commonly described with detailed imaging follow-up.