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Low serum apolipoprotein A-I level in patients with vasospastic angina
1Second Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Insights
Apolipoprotein A-I levels were lower in patients with vasospastic angina compared to healthy individuals. This suggests apolipoprotein A-I may help prevent vasospastic angina, a condition affecting coronary arteries.
Area of Science:
- Cardiology
- Lipidology
- Biochemistry
Background:
- Vasospastic angina is a condition characterized by temporary narrowing of the coronary arteries.
- Lipid and lipoprotein profiles are crucial in cardiovascular health and disease.
- Understanding the biochemical factors contributing to vasospastic angina is essential for prevention and treatment.
Purpose of the Study:
- To compare serum lipid and lipoprotein levels between patients with vasospastic angina and a control group.
- To investigate the potential role of specific lipoproteins, particularly apolipoprotein A-I, in the pathophysiology of vasospastic angina.
Main Methods:
- Serum samples were collected from 15 patients diagnosed with vasospastic angina.
- A control group of 33 individuals with no angiographic coronary stenosis and no vasospastic angina was included.
- Intracoronary acetylcholine infusion was used to assess vasospastic response.
- Serum levels of cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein A-I, apolipoprotein A-II, and apolipoprotein B were measured.
Main Results:
- Patients with vasospastic angina exhibited significantly lower serum levels of apolipoprotein A-I (112 +/- 6 mg/dl) compared to the control group (128 +/- 4 mg/dl) (p < 0.05).
- No significant differences were observed between the groups in serum levels of cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein A-II, and apolipoprotein B.
Conclusions:
- Reduced serum levels of apolipoprotein A-I may be associated with an increased risk or presence of vasospastic angina.
- Apolipoprotein A-I might play a protective role in preventing vasospastic angina.
- Further research is warranted to elucidate the precise mechanisms linking apolipoprotein A-I to vasospastic angina.
Abstract:
The serum lipid and lipoprotein levels in 15 patients with vasospastic angina were compared with those in 33 patients with no angiographic coronary stenosis and no vasospastic angina after intracoronary acetylcholine infusion. The serum level of apolipoprotein A-I in patients with vasospastic angina (112 +/- 6 mg/dl) was significantly lower (p < 0.05) than that in patients without vasospasm (128 +/- 4 mg/dl). However, there were no differences between the two groups in the serum levels of cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoprotein A-II, and apolipoprotein B. Thus apolipoprotein A-I may play some role in the prevention of vasospastic angina.