Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biphasic versus sequential pulse defibrillation: a direct comparison in humans

D L Jones1, G J Klein, G M Guiraudon

  • 1Department of Medicine, University of Western Ontario, London, Canada.

American Heart Journal
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plant species-specific rhizobiome assembly in the hyper-arid Atacama Desert.

Frontiers in microbiology·2025
Same author

City-wide wastewater genomic surveillance through the successive emergence of SARS-CoV-2 Alpha and Delta variants.

Water research·2022
Same author

Establishment of local wastewater-based surveillance programmes in response to the spread and infection of COVID-19 - case studies from South Africa, the Netherlands, Turkey and England.

Journal of water and health·2022
Same author

Quantifying citrate-enhanced phosphate root uptake using microdialysis.

Plant and soil·2021
Same author

Quantifying the frequency and volume of urine deposition by grazing sheep using tri-axial accelerometers.

Animal : an international journal of animal bioscience·2021
Same author

Overriding water table control on managed peatland greenhouse gas emissions.

Nature·2021

Sequential pulse defibrillation, using three electrodes, delivered less energy than biphasic shocks in patients undergoing arrhythmia surgery. This finding highlights sequential pulsing as an effective defibrillation method.

Area of Science:

  • Cardiology
  • Medical Devices
  • Electrophysiology

Background:

  • Biphasic and sequential pulse defibrillation shocks are superior to monophasic shocks.
  • Limited data directly compares biphasic and sequential pulse defibrillation under controlled conditions.

Purpose of the Study:

  • To compare the defibrillation threshold of biphasic and sequential pulse shocks intraoperatively.
  • To evaluate waveform efficacy while maintaining constant pulse characteristics, subjects, and total electrode surface area.

Main Methods:

  • Intraoperative defibrillation threshold determination in 12 arrhythmia surgery patients.
  • Randomized crossover design comparing biphasic and sequential pulse shocks.
  • Use of two or three patch electrodes with constant total electrode surface area.

Related Experiment Videos

Main Results:

  • Sequential pulse shocks required significantly lower delivered energy (3.6 +/- 0.7 joules) compared to biphasic shocks (5.5 +/- 0.9 joules).
  • Leading-edge delivered current was also lower with sequential pulse shocks.

Conclusions:

  • Sequential pulse defibrillation with three electrodes offers a superior current delivery system compared to biphasic shocks with two electrodes.
  • This study provides evidence for the effectiveness of sequential pulse defibrillation in a controlled clinical setting.