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A DNA polymerase alpha-associated 56 kDa protein kinase
V M Peck1, E W Gerner, A E Cress
1Department of Radiation Oncology, University of Arizona Health Sciences Center, University of Arizona, Tucson 85724.
Biochemical and Biophysical Research Communications
|January 29, 1993
Abstract:
Initiation of chromosomal DNA replication must be carefully regulated during the cell cycle. We report that Drosophila embryo DNA polymerase alpha complex, isolated by immunological techniques, contains a protein kinase activity. The kinase will phosphorylate histone H1, but prefers peptides contained in the DNA polymerase alpha-kinase complex. Renaturation experiments determined that the kinase activity resides in a 56-kDa peptide.