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Updated: Aug 19, 2026

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue
R Dittadi1, P M Donisi, A Brazzale
1Center for the Study of Biological Markers of Malignancy, Regional General Hospital, Venice, Italy.
Abstract:
Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
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