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Melanoma associated with ring chromosome 7

S Vollenweider Roten1, C D Delozier-Blanchet, I Masouyé

  • 1Department of Dermatology, University Hospital, Geneva, Switzerland.

Dermatology (Basel, Switzerland)
|January 1, 1993
PubMed
Summary

A rare ring chromosome 7 anomaly in a teen was linked to multiple moles and malignant melanoma. This case suggests a potential genetic connection between chromosome 7 abnormalities and skin cancer development.

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Area of Science:

  • Genetics and Oncology
  • Dermatology

Background:

  • Constitutional chromosome anomalies can predispose individuals to various health conditions.
  • Ring chromosome 7 (R7) is a rare chromosomal abnormality associated with specific phenotypic features.
  • Malignant melanoma is a serious form of skin cancer with complex genetic underpinnings.

Observation:

  • A 17-year-old female presented with multiple pigmented skin lesions and a constitutional ring chromosome 7.
  • This patient subsequently developed malignant melanoma, a rare occurrence in individuals with R7.
  • Literature review revealed eight other R7 cases, all exhibiting vascular or pigmented skin lesions, but none with malignant tumors prior to this report.

Findings:

  • The patient with ring chromosome 7 developed malignant melanoma.
  • This represents the first documented case of malignant tumor development in individuals with R7.
  • A significant proportion of reported R7 patients exhibit pigmented skin lesions, suggesting a potential predisposition.

Implications:

  • The findings suggest a possible non-fortuitous association between constitutional ring chromosome 7 and the development of malignant melanoma.
  • Further genetic research into chromosome 7 anomalies and their role in melanoma pathogenesis is warranted.
  • This case highlights the importance of vigilant dermatological surveillance in patients with rare chromosomal abnormalities and associated skin findings.

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