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Prostate cancer. Radiation therapy for localized disease
M A Bagshaw1, I D Kaplan, R C Cox
1Department of Radiation Oncology, Stanford University School of Medicine, California 94305.
Cancer
|February 1, 1993
Summary
External beam radiation therapy is safe and effective for prostate cancer, with 15-year survival rates varying by tumor extent. Advanced cases may benefit from combined therapies for improved outcomes.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Prostate cancer treatment has utilized various radiation modalities since 1910.
- External beam x-irradiation is a key modality in radiation oncology.
Purpose of the Study:
- To evaluate the safety and efficacy of external beam x-irradiation for prostate cancer.
- To determine survival rates based on tumor characteristics and treatment parameters.
Main Methods:
- Analysis of 1119 patients treated with curative intent between 1956-1990.
- Utilized medium energy linear accelerators for external beam x-irradiation.
- Administered tumor doses of 70 Gy at 10 Gy/wk.
Main Results:
- Achieved 15-year survival rates from 18% to 50%, depending on tumor localization.
- Survival rates are inversely proportional to clinical stage and histopathologic grade.
- Demonstrated safety and effectiveness of the prescribed radiation doses.
Conclusions:
- External beam radiation therapy is a safe and effective treatment for prostate cancer.
- Combining external beam with interstitial irradiation could improve outcomes for advanced tumors.
- Hyperthermia or other sensitizers may enhance biological dose and treatment efficacy.