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Allergic bronchopulmonary aspergillosis

L M Vaughan1

  • 1College of Pharmacy, Medical University of South Carolina, Charleston 29425-0810.

Clinical Pharmacy
|January 1, 1993
PubMed
Summary

Allergic bronchopulmonary aspergillosis (ABPA) is an immune response to Aspergillus fumigatus, often complicating asthma and cystic fibrosis. Early diagnosis and corticosteroid treatment are crucial to prevent severe lung damage and fatalities.

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Area of Science:

  • Pulmonology
  • Immunology
  • Allergy

Background:

  • Allergic bronchopulmonary aspergillosis (ABPA) is an immune-mediated lung disease.
  • It results from an allergic reaction to Aspergillus fumigatus antigens.
  • ABPA is a significant complication in patients with asthma and cystic fibrosis.

Purpose of the Study:

  • To describe the history, clinical features, diagnosis, treatment, and monitoring of ABPA.
  • To emphasize the importance of early diagnosis for effective management.
  • To outline strategies for preventing fibrotic lung complications.

Main Methods:

  • Review of historical data and clinical presentations of ABPA.
  • Identification of diagnostic criteria including clinical, serological, and radiological findings.
  • Evaluation of treatment protocols, primarily focusing on oral corticosteroids and monitoring parameters.

Main Results:

  • ABPA diagnosis relies on criteria such as bronchial obstruction, eosinophilia, and specific antibodies to Aspergillus.
  • Total serum IgE and chest X-rays are key for monitoring treatment response.
  • Oral prednisone is the primary treatment, with specific dosing and tapering schedules.

Conclusions:

  • ABPA is a potentially fatal inflammatory pulmonary disease.
  • Early diagnosis and prompt corticosteroid therapy can prevent irreversible lung damage.
  • Effective monitoring of IgE levels and imaging is essential for managing ABPA and minimizing treatment side effects.

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