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High-performance liquid chromatographic method for the determination of dimethindene in urine
D Chollet1, P Künstner, M Wermeille
1Department of Toxicology and Pharmacokinetics, Zyma SA, CH-1260, Nyon, Switzerland.
Journal of Chromatography
|January 15, 1993
Abstract:
An automated high-performance liquid chromatographic assay, using on-line solid-phase extraction, is described for the determination of dimethindene in urine. The solid-phase extraction of the sample (1000 microliters) and the elution of the drug on to the analytical column are performed automatically and concomitantly. The limit of quantification is 5 pmol/ml.