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Updated: Oct 9, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Injectable collagen and autoimmune disease
Background:
The media and litigation in the United States have alleged a link between the use of injectable bovine collagen and the development of autoimmune disease, specifically dermatomyositis/polymyositis.
Objective:
To present the scientific and epidemiologic data with regard to this issue.
Methods:
Literature was reviewed as well as reports to Collagen Corporation and the litigation.
Results:
After review of the literature and review of data currently available to Collagen Corporation, no link can be established at this time between collagen injectable material and autoimmune disease, specifically dermatomyositis/polymyositis.
Conclusion:
There are no epidemiologic or scientific data to support the alleged link in the media and litigation between injectable bovine collagen material and dermatomyositis/polymyositis.
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