Negative-pressure pulmonary edema after endotracheal intubation

A review of complications occurring in conjunction with general anesthesia identified eight patients with laryngospasm-induced negative-pressure pulmonary edema after endotracheal intubation. Six male and two female patients (mean age, 31.9 years) developed pulmonary edema immediately or up to 25 minutes after extubation. Radiographs obtained 15-165 minutes after symptoms developed revealed alveolar edema and predominating interstitial edema in four patients each. Seven of eight had bilateral centralized patterns, and one had unilateral pulmonary edema. The mean vascular pedicle width was 67 mm +/- 12, a value 40% higher than the normal mean of 48 mm. The mean cardiothoracic ratio was 0.54 +/- .07 (normal mean, 0.53). There were no radiologic abnormalities of the trachea. Negative-pressure pulmonary edema should be suspected in young patients with findings of bilateral centralized pulmonary edema, a wide vascular pedicle, and a normal cardiothoracic ratio in the immediate postoperative period.