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Related Experiment Videos

Growth hormone-induced glomerular hyperfiltration is dependent on vasodilating prostanoids

B Tönshoff1, R Nowack, S Kurilenko

  • 1Department of Pediatrics, University of Heidelberg, Germany.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 1, 1993
PubMed
Summary

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Growth hormone (GH) increases kidney function in healthy women. This effect is blocked when prostaglandin production is inhibited, suggesting prostaglandins are essential for GH-induced kidney improvements.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Exogenous growth hormone (GH) and insulin-like growth factor (IGF)-I impact renal hemodynamics.
  • The precise mechanisms of GH-induced renal effects in humans remain unclear.
  • Prostaglandins (PG) are known vasodilators that may influence renal function.

Purpose of the Study:

  • To investigate if vasodilating prostaglandins are required for the renal hemodynamic response to exogenous GH in humans.
  • To determine the role of prostaglandins in mediating the increase in glomerular filtration rate (GFR) induced by GH.

Main Methods:

  • An intraindividual cross-over study in 10 healthy women.
  • Treatment with recombinant human GH (rhGH) for 3 days, with and without indomethacin (a prostaglandin inhibitor).

Related Experiment Videos

  • GFR measured as inulin clearance (Cin) before and after rhGH administration.

    • Main Results:

    • rhGH treatment increased serum IGF-I by 50% and GFR by 10% (P < 0.03).
    • The GH-induced increase in GFR was completely blocked when indomethacin was coadministered.
    • Urinary PGE2 excretion decreased with indomethacin, as expected, and was not stimulated by rhGH.

    Conclusions:

    • The increase in GFR observed during GH treatment in humans is mediated by or requires the presence of vasodilating prostanoids.
    • Prostaglandins play a crucial role in mediating the renal hemodynamic effects of GH in healthy individuals.