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Related Experiment Videos

Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose

W E Haefeli1, R A Schoenenberger, P Weiss

  • 1Department of Internal Medicine, University Hospital (Kantonsspital), Basel, Switzerland.

The American Journal of Medicine
|February 1, 1993
PubMed
Summary

Acyclovir overdose can cause severe neurotoxicity with a 24-48 hour delay after peak levels. This delayed onset suggests early intervention like hemodialysis may prevent central nervous system toxicity.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Nephrology

Background:

  • Acyclovir is an antiviral medication.
  • Central nervous system (CNS) side effects are known complications of acyclovir therapy.
  • Understanding the concentration-effect relationship is crucial for managing toxicity.

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