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Postischemic hypoperfusion during unilateral lung reperfusion in vivo
R J Gilroy1, M J Bhatte, N E Wickersham
1Department of Medicine (Pulmonary and Critical Care), Vanderbilt University, Nashville, Tennessee.
The American Review of Respiratory Disease
|February 1, 1993
Summary
Lung reperfusion injury involves increased vascular resistance and microvascular permeability, leading to reduced blood flow. This study in sheep demonstrates impaired lung blood flow during reperfusion, suggesting new therapeutic targets.
Area of Science:
- Pulmonary Medicine
- Cardiovascular Physiology
- Surgical Research
Background:
- Incomplete blood flow restoration during reperfusion can worsen injury.
- The "no-reflow" phenomenon is well-documented in systemic organs.
- Lung reperfusion injury's impact on blood flow and microvascular function requires further investigation.
Purpose of the Study:
- To investigate alterations in lung blood flow and microvascular function during lung reperfusion injury in vivo.
- To determine if hypoperfusion occurs in the reperfused lung.
- To assess changes in pulmonary vascular resistance and microvascular permeability.
Main Methods:
- Utilized a unilateral lung ischemia-reperfusion model in awake sheep.
- Measured pulmonary vascular resistance using radiolabeled microspheres.
- Assessed microvascular permeability with an indicator dilution method using butanediol.
Main Results:
- Pulmonary vascular resistance in the reperfused lung increased threefold after reperfusion.
- The reperfused lung's increased resistance accounted for the overall rise in pulmonary vascular resistance.
- Microvascular permeability in the reperfused lung increased by 52% compared to the contralateral lung.
Conclusions:
- Lung reperfusion injury is associated with significant changes in vascular resistance and microvascular function.
- Postischemic hypoperfusion occurs in the lung during reperfusion in vivo.
- Findings suggest potential new therapeutic strategies for clinical disorders involving lung reperfusion injury.