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Related Experiment Videos

Increased lower airways responsiveness associated with sinusitis in a rabbit model

S M Brugman1, G L Larsen, P M Henson

  • 1Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

The American Review of Respiratory Disease
|February 1, 1993
PubMed
Summary

Sterile sinusitis can increase lower airways responsiveness to histamine in rabbits. This effect is likely due to postnasal dripping, not a nasobronchial reflex or mediator absorption.

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Area of Science:

  • Respiratory Medicine
  • Immunology
  • Otolaryngology

Background:

  • The link between sinusitis and asthma is known but debated.
  • Understanding this connection is crucial for respiratory health.

Purpose of the Study:

  • To investigate the relationship between sinusitis and lower airway function.
  • To explore potential mechanisms linking sinusitis to airway hyperresponsiveness.

Main Methods:

  • A rabbit model of sterile maxillary sinusitis was established using C5a des arg.
  • Airways responsiveness (AWR) to histamine was measured in various experimental conditions.
  • Mechanisms including postnasal dripping, nasobronchial reflex, and mediator absorption were assessed.

Main Results:

Related Experiment Videos

  • Experimental sinusitis significantly increased AWR to histamine in head-up rabbits.
  • No increased AWR was observed in control animals or when fluid passage to lower airways was blocked.
  • Neither histology nor bronchoalveolar lavage showed significant lower airway inflammation.

Conclusions:

  • Sterile sinusitis can enhance lower airway responsiveness in a rabbit model.
  • Postnasal dripping of cells or cell products is the probable mechanism.
  • Nasobronchial reflex and inflammatory mediator absorption were not supported by this model.