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Intrapleural quinacrine instillation for recurrent pneumothorax or persistent air leak
H M Janzing1, A Derom, E Derom
1Surgical Department, University Hospital, Ghent, Belgium.
The Annals of Thoracic Surgery
|February 1, 1993
Summary
Chemical pleurodesis using quinacrine is a safe and effective treatment for recurrent pneumothorax and persistent air leak. This low-dose regimen minimized side effects and prevented late recurrences.
Area of Science:
- Thoracic Surgery
- Pulmonology
- Medical Therapeutics
Background:
- Recurrent pneumothorax and persistent air leak pose significant clinical challenges.
- Effective pleurodesis is crucial for managing these conditions and preventing recurrence.
Purpose of the Study:
- To evaluate the safety and efficacy of intrapleural quinacrine for pleurodesis.
- To assess recurrence rates and complications associated with quinacrine pleurodesis.
Main Methods:
- A standardized scheme for intrapleural quinacrine administration was used in 27 patients (28 episodes).
- Patients underwent evaluations at 1 month and a follow-up check-up in August 1990.
- Quinacrine plasma concentrations were measured in a subset of patients.
Main Results:
- One early failure was observed; however, no late recurrences occurred.
- Transient fever was the primary side effect; no serious or late complications were noted.
- Low quinacrine plasma concentrations (< 10 ng/mL) were detected, indicating minimal systemic absorption.
Conclusions:
- Intrapleural quinacrine is a safe and effective method for chemical pleurodesis.
- A low-dose regimen with careful administration is key to preventing morbidity and recurrence.
- Quinacrine offers an advantage over other agents due to reduced pain.