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Where the kidney is concerned, how much mannitol is too much?
G M Rabetoy1, M R Fredericks, C F Hostettler
1Department of Internal Medicine, Naval Hospital, San Diego, CA.
The Annals of Pharmacotherapy
|January 1, 1993
Summary
High doses of mannitol can cause acute renal failure (ARF). While hemodialysis may reverse ARF, limiting mannitol dosage is crucial for prevention.
Area of Science:
- Nephrology
- Neurology
- Pharmacology
Background:
- Mannitol is commonly used to reduce intracranial pressure.
- Acute renal failure (ARF) is a potential complication of mannitol administration.
- Understanding the dose-response relationship is critical for patient safety.