Related Experiment Videos
Ceftriaxone-induced acute pancreatitis
A E Zimmermann1, B G Katona, J S Jodhka
1Department of Pharmacy, Harbor Hospital Center, Baltimore, MD 21230.
The Annals of Pharmacotherapy
|January 1, 1993
Summary
Ceftriaxone, an antibiotic, may cause acute pancreatitis. A patient with short-bowel syndrome developed pancreatitis after receiving ceftriaxone, with symptoms resolving after discontinuation, suggesting a probable drug-induced adverse effect.
Area of Science:
- Gastroenterology
- Pharmacology
- Clinical Medicine
Background:
- Short-bowel syndrome (SBS) patients often require home total parenteral nutrition (TPN).
- Catheter-related bloodstream infections (CRBSI) are a common complication in TPN-dependent patients.
- Antibiotic therapy is crucial for managing sepsis in immunocompromised individuals.
Observation:
- A TPN-dependent SBS patient developed gram-negative catheter sepsis.
- The patient was treated with intravenous ceftriaxone for sepsis.
- Following ceftriaxone initiation, the patient presented with symptoms of acute pancreatitis.
Findings:
- The patient exhibited elevated lipase and amylase levels, jaundice, and abdominal pain.
- Discontinuation of ceftriaxone led to the resolution of pancreatitis symptoms.
- No other causative factors for pancreatitis were identified.
Implications:
- Ceftriaxone is a potential cause of drug-induced acute pancreatitis.
- Clinicians should consider ceftriaxone when evaluating patients with acute pancreatitis.
- Further research is needed to elucidate the mechanism of ceftriaxone-induced pancreatitis.