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Related Experiment Videos

Using memory for pain in analgesic research

N Babul1, A C Darke, D H Johnson

  • 1Department of Scientific Affairs, Purdue Frederick, Pickering, Ontario, Canada.

The Annals of Pharmacotherapy
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Pain recall at 24 and 48 hours accurately reflects hourly pain assessments in analgesic studies. This validates using recalled pain intensity for evaluating drug effectiveness in clinical trials.

Area of Science:

  • Pain research
  • Clinical pharmacology
  • Analgesic studies

Background:

  • Accurate pain assessment is crucial for evaluating analgesic efficacy.
  • Hourly pain intensity assessments can be burdensome in clinical trials.
  • Exploring alternative methods for pain measurement is essential.

Purpose of the Study:

  • To validate pain intensity recall at 24 and 48 hours as a substitute for hourly pain assessments.
  • To determine if recalled pain intensity can reliably replace continuous pain monitoring in analgesic studies.

Main Methods:

  • Eighty-four patients undergoing anterior cruciate ligament reconstruction participated.
  • Patients provided hourly pain intensity ratings (visual analog scale) for 48 hours.
  • Pain recall (worst, least, usual) was assessed at 24 and 48 hours.

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Main Results:

  • Pain recall (worst, least, usual) strongly correlated with experienced pain (Pearson r = 0.80-0.89, p < 0.0001).
  • Usual pain recall demonstrated the highest correlation with hourly pain measurements.
  • No significant differences were found between recalled and experienced pain, except for 48-hour recall of worst pain.

Conclusions:

  • Pain recall is a valid and reliable method for assessing pain intensity in clinical trials.
  • The findings support the use of pain recall as a practical alternative to hourly assessments.
  • This approach can enhance the efficiency of repeated-dose analgesic studies.