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Oncocytic variant of choroid plexus papilloma. Evolution from benign to malignant "oncocytoma"
1Department of Neuropathology, Walton Centre for Neurology and Neurosurgery, Walton Hospital, Liverpool, United Kingdom.
Background:
The case of a left temporoparietal choroid plexus papilloma in a 12-year-old girl, which recurred 12 months after subtotal resection and apparent full recovery, is described.
Methods:
The two consecutive surgical specimens were studied by light and electron microscopy.
Results:
The first surgical specimen showed a tumor composed of cells with distended cytoplasm packed with numerous mitochondria characteristic of "oncocytic" change. Thus, tumor was the rare benign oncocytic variant of choroid plexus papilloma. A repeat histologic study of the recurrent tumor 12 months later showed evidence of malignant evolution in the form of multinucleated cells with frequent, often bizarre, mitotic figures.
Conclusion:
A rarely described oncocytic variant of choroid plexus papilloma that showed evidence of evolution from benign to malignant "oncocytoma" is discussed.