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Disruption of the 3' phosphoglycerate kinase (pgk) gene in Aspergillus nidulans
1Department of Genetics, University of Leicester, UK.
Current Genetics
|February 1, 1993
Abstract:
We report the isolation of a pgk- mutant strain of Aspergillus nidulans by means of a gene disruption strategy, and demonstrate that the pgk gene is located on chromosome VIII. The pgk- mutant conidiates poorly, will only grow on media supplemented with both a glycolytic and a gluconeogenic carbon source, and is inhibited by hexoses.