Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does the ileocolonic junction differentiate between solids and liquids?

J Hammer1, M Camilleri, S F Phillips

  • 1Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905.

Gut
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Experimental Limit on the Permanent Electric Dipole Moment of the Deuteron.

Physical review letters·2026
Same author

Real-world evidence reported for clinical efficacy evaluation in European Public Assessment Reports of authorised targeted therapies for solid malignancies: a comprehensive review (2018-2022).

ESMO real world data and digital oncology·2026
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

ACE-RT, A Cloud-Based Tool for Remote Radiotherapy Contouring Support in Lower-Resourced Settings: A Pilot Evaluation.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Outcomes and level of evidence in radiation therapy research and different categories of radiotherapy innovations: an ESTRO-VBRO bibliometrics analysis of the literature.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025

The distal ileum can differentiate between solids and liquids, influencing how contents move into the colon. However, the ileocecal junction does not distinguish between solid and liquid transit.

Area of Science:

  • Gastroenterology
  • Digestive Physiology
  • Human Physiology

Background:

  • Previous studies suggested ileal bolus movements fill the colon.
  • The mechanism of solid-liquid discrimination in ileal transit was unclear.

Purpose of the Study:

  • To test if ileal bolus transit into the colon differentiates between solids and liquids.
  • To investigate the role of the distal ileum and ileocecal junction in this process.

Main Methods:

  • 13 healthy volunteers underwent ileal infusion of radiolabeled solid (111In resin pellets) and liquid (99mTc-DTPA) markers.
  • Scintigraphy quantified transit from ileum to colon; ileal motility was also monitored.
  • Markers were infused at proximal (100 cm) and distal (<50 cm) ileal locations.

Related Experiment Videos

Main Results:

  • Discriminant transit (liquids faster than solids) was observed when markers were infused in the proximal ileum.
  • No separate solid-liquid transit was seen when markers were instilled in the distal ileum.
  • No consistent ileal motor pattern correlated with colonic filling.

Conclusions:

  • The distal ileum demonstrates the capacity to discriminate between solid and liquid contents.
  • The ileocecal junction appears unable to differentiate between solid and liquid transit.
  • Ileal content processing influences subsequent colonic filling.