Related Experiment Video
Updated: Aug 13, 2026

12:06
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Intrascleral nerve loop mistakenly identified as a foreign body
Archives of Ophthalmology (Chicago, Ill. : 1960)
|March 1, 1977
Summary
A pigmented lesion on a 5-year-old boy's sclera, initially suspected to be a graphite foreign body, was surgically removed. Histological examination revealed it to be an intrascleral nerve loop (Axenfeld), a rare anatomical finding.
Area of Science:
- Ophthalmology
- Histopathology
- Pediatric Ophthalmology
Background:
- Scleral lesions in children can present diagnostic challenges.
- Pigmented lesions require careful evaluation to rule out malignancy or unusual anatomical variations.
- Foreign body sensation in the eye is a common complaint, but the etiology can vary.
Observation:
- A 5-year-old male presented with a pigmented lesion on the sclera.
- The lesion was clinically presumed to be a foreign body, likely graphite from a pencil.
- An excisional biopsy was performed for diagnosis and treatment.
Findings:
- Histopathological examination of the excised lesion was performed.
- The study identified the pigmented scleral lesion as an intrascleral nerve loop (Axenfeld).
- This finding represents a rare anatomical variation rather than a foreign body.
Implications:
- Accurate histological diagnosis is crucial for managing scleral lesions.
- Intrascleral nerve loops should be considered in the differential diagnosis of pigmented scleral findings.
- This case highlights the importance of biopsy in resolving diagnostic uncertainty in pediatric eye conditions.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...

