[Diffusion of cefamandole into the prostatic tissue (author's transl)]

Area of Science:

• Pharmacokinetics and Drug Metabolism
• Infectious Disease Therapeutics
• Urology

Context:

• Benign prostatic hyperplasia (BPH) affects a significant portion of the aging male population.
• Prostate infections require antibiotics with adequate tissue penetration.
• Understanding antibiotic concentrations in prostate tissue is crucial for effective treatment.

Purpose:

• To determine serum and prostatic tissue concentrations of cefamandole after intravenous administration.
• To compare cefamandole's tissue distribution with other cephalosporins.
• To evaluate the suitability of cefamandole for treating prostatic infections.

Summary:

• Serum and prostatic adenoma tissue concentrations of cefamandole were measured in 21 patients (average age 69 years) after a single 2g IV dose.
• Mean serum concentrations were 104.8 µg/ml at 30 min and 51 µg/ml at 60 min.
• Mean prostatic tissue concentrations were 32.87 µg/g at 30 min and 17.1 µg/g at 60 min.

Impact:

• The determined cefamandole concentrations in serum and prostate tissue suggest its efficacy in treating infections caused by cefamandole-susceptible microorganisms.
• Provides valuable pharmacokinetic data for clinicians managing prostate infections.
• Informs antibiotic selection for urological infections.