Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adventitial elastolysis is a primary event in aneurysm formation

J V White1, K Haas, S Phillips

  • 1Frederick A. Reichle Surgical Research Laboratory, Temple University Medical School, Philadelphia, PA 19140.

Journal of Vascular Surgery
|February 1, 1993
PubMed
Summary

Adventitial elastin loss is a primary event in abdominal aortic aneurysm (AAA) formation. This significant degradation occurs before structural integrity loss and aneurysm expansion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining plant and dairy proteins to enhance the oxidative stability of microencapsulated lipids in spray-dried powders.

Food chemistry·2026
Same author

Retention of Placenta.

The Southern medical record·2022
Same author

Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP).

Infection·2021
Same author

[Ventilation Patients between Acute Care and Long-term Out-of-Hospital Ventilation - Routine Documentation based Analysis of the Care Situation].

Pneumologie (Stuttgart, Germany)·2021
Same author

[Ventilation Patients between Acute Care and Long-term Out-of-Hospital Ventilation - Routine Documentation based Analysis of the Care Situation].

Pneumologie (Stuttgart, Germany)·2021
Same author

Evaluation of pulsed electric fields technology for the improvement of subsequent carotenoid extraction from dried Rhodotorula glutinis yeast.

Food chemistry·2020

Area of Science:

  • Vascular Biology
  • Biomedical Engineering
  • Histopathology

Background:

  • Adventitial elastin degradation is a key feature of abdominal aortic aneurysm (AAA) in humans.
  • The precise quantitative link between elastin reduction and AAA initiation/progression remains unclear.

Purpose of the Study:

  • Quantify adventitial elastin reduction in small AAA.
  • Determine if elastin loss correlates with aneurysm growth.
  • Investigate the ultrastructure of residual elastin.

Main Methods:

  • Aortic wall samples from 12 AAA patients (small, moderate, large) and 6 controls were analyzed.
  • Histologic and scanning electron microscopy evaluated elastin and collagen.
  • Adventitial elastin content was quantified via video microscopy.

Related Experiment Videos

Main Results:

  • Normal aortas show compacted elastin and collagen lamellae; AAA walls exhibit disruption.
  • Remaining elastin fibers in AAA were disorganized and tortuous.
  • A significant reduction (81.6% in lamellae, 85.7% in fibers) in adventitial elastin was observed compared to controls (p < 0.001).
  • Aneurysm size did not influence adventitial elastin content.

Conclusions:

  • Elastolysis is a primary event preceding structural weakening and small AAA development.
  • Significant adventitial elastin loss is a critical factor in AAA pathogenesis.