[Multiple organ failure related to disseminated intravascular coagulation]

This paper describes the main pathophysiological events leading to multiple organ failure (MOF) related to disseminated intravascular coagulation (DIC), caused by circulatory failure or infection. The main mechanisms responsible for the development of MOF in DIC are discussed, as are both the organ ischemia due to stasis and/or obstruction and the close interrelated reactions between inflammatory reaction, immune system and coagulation systems, especially focused on the close connection between the endothelium and superimposed mediators.