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Updated: Aug 11, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Actinic keratosis. A premalignant skin lesion
1Department of Dermatology, Geisinger Clinic, Danville, PA 17822.
Abstract:
The actinic keratotic lesion appearing on the sun-exposed skin of the middle-aged and elderly is a common premalignant lesion that infrequently becomes squamous cell carcinoma. Generally, superficially destructive measures provide adequate therapy for this epidermal dysplastic growth. Because of the rare threat of squamous cell carcinoma, a therapeutic dilemma results. If the physician detects any signs of malignancy, such as palpability, induration, or bleeding, a biopsy is mandatory for confirmation.
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