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New and old immunodeficiencies
1UCLA Department of Pediatrics, UCLA School of Medicine 90024.
Pediatric Research
|January 1, 1993
Summary
Immunodeficiency research has evolved from clinical associations to genetic and molecular studies. Future research will focus on novel defects like neutropenic syndromes and natural killer cell deficiencies.
Area of Science:
- Immunology
- Genetics
- Pediatrics
Background:
- Immunodeficiencies were initially recognized by clinical and familial associations starting in the 1920s.
- A significant period of discovery from 1950-1965 led to the identification of primary immunodeficiencies affecting major immune system components.
- The understanding of immunodeficiencies has shifted towards immunologic and genetic aspects, with a notable increase in identified syndromes.