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Platelet-derived growth factor in renal development and disease
1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Seminars in Nephrology
|January 1, 1993
Summary
Platelet-derived growth factor (PDGF) plays a crucial role in kidney development and disease by influencing cell proliferation and matrix deposition. Targeting PDGF may offer new therapeutic strategies for kidney disorders.
Area of Science:
- Nephrology
- Developmental Biology
- Cell Biology
Background:
- Platelet-derived growth factor (PDGF) is implicated in various cellular processes.
- Its role in kidney development and disease pathogenesis requires further elucidation.
Purpose of the Study:
- To review the evidence supporting the role of PDGF in human kidney development and disease.
- To explore potential therapeutic targets within the PDGF system.
Main Methods:
- Literature review of studies investigating PDGF expression and function in renal cells.
- Analysis of PDGF's effects on mesangial cells and interstitial fibroblasts.
Main Results:
- PDGF is critical at local glomerular and interstitial sites in kidney development and disease.
- PDGF stimulates proliferation, matrix deposition, chemotaxis, and contraction in renal cells.
- PDGF mediates constructive processes in development (glomerulogenesis, vascularization) and destructive processes in disease (proliferative and sclerotic glomerulopathies).
Conclusions:
- PDGF is essential for normal kidney development and contributes to disease progression.
- Therapeutic targeting of the PDGF system holds promise for treating kidney diseases.