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Fructose breath hydrogen tests

J H Hoekstra1, A A van Kempen, S B Bijl

  • 1Department of Paediatrics, Bosch Medicentrum, 's-Hertogenbosch, The Netherlands.

Archives of Disease in Childhood
|January 1, 1993
PubMed
Summary
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This study shows that children aged 1-3 years have difficulty absorbing fructose, similar to toddler diarrhea. Higher fructose doses (2 g/kg) led to incomplete absorption in all children tested.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Digestive Health

Background:

  • Fructose malabsorption is a common issue affecting children's digestive health.
  • Understanding fructose absorption in young children is crucial for diagnosing and managing gastrointestinal symptoms.

Purpose of the Study:

  • To investigate fructose absorption in healthy children aged 0.1-6 years using the breath hydrogen test.
  • To determine the impact of different fructose dosages (1 g/kg and 2 g/kg) on absorption rates.
  • To explore the correlation between fructose malabsorption and age, particularly in relation to toddler diarrhea.

Main Methods:

  • A cohort of 114 healthy children aged 0.1-6 years participated in the study.
  • Children were administered either 1 g/kg or 2 g/kg of fructose.

Related Experiment Videos

  • Fructose absorption was assessed using the breath hydrogen test, with peak excretions measured.

    • Main Results:

    • All children (100%) receiving 2 g/kg of fructose exhibited incomplete absorption (peak breath hydrogen ≥ 20 ppm).
    • At a 1 g/kg dose, 44% (25/57) of children showed incomplete fructose absorption.
    • Incomplete absorption and higher peak hydrogen values were significantly more prevalent in children aged 1-3 years.

    Conclusions:

    • Children aged 1-3 years demonstrate a higher incidence of fructose malabsorption.
    • The findings suggest a potential link between fructose malabsorption in this age group and the occurrence of toddler diarrhea.
    • Dosage significantly impacts fructose absorption, with higher amounts leading to malabsorption in all tested children.