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Endocrine disease

L D Hordon1, V Wright

  • 1Rheumatology and Rehabilitation Research Unit, University of Leeds, UK.

Current Opinion in Rheumatology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Endocrine diseases significantly impact bone mass, affecting thyroid disorders, hyperparathyroidism, and growth hormone deficiencies. Research explores diabetic bone disease and pregnancy

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Rheumatology

Background:

  • Endocrine diseases are recognized for their significant impact on skeletal health and bone mass.
  • Previous research has explored various endocrine conditions affecting bone, including thyroid disease, primary hyperparathyroidism, and growth hormone deficiency.
  • The interplay between autoimmune conditions and endocrine disorders, such as Graves' disease and connective tissue disease, warrants further investigation.

Purpose of the Study:

  • To review the effects of endocrine diseases on bone mass.
  • To investigate the impact of growth hormone replacement in adults with panhypopituitarism and bone mass in children with treated growth hormone deficiency.
  • To examine the pathogenesis of diabetic bone disease and the influence of pregnancy on rheumatoid arthritis.

Main Methods:

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  • Literature review and analysis of existing studies on endocrine disorders and bone health.
  • Examination of data on growth hormone replacement therapy and its skeletal effects.
  • Review of studies investigating diabetic bone disease mechanisms and pregnancy-induced remission in rheumatoid arthritis.

Main Results:

  • Children with treated growth hormone deficiency may achieve low bone mass in adulthood.
  • Asymptomatic primary hyperparathyroidism indications for surgery have been reviewed.
  • Graves' disease patients do not show an increased risk of systemic autoimmune disease despite positive antinuclear antibodies.
  • Diabetic bone disease involves calcium malabsorption, hypercalciuria, reduced bone formation, and collagen abnormalities.
  • Diabetic control, joint mobility, nephropathy, and retinopathy are interconnected.
  • Pregnancy may induce remission in rheumatoid arthritis through discussed mechanisms.

Conclusions:

  • Endocrine diseases present complex challenges to bone health, requiring continued investigation.
  • Understanding the specific mechanisms of bone loss in various endocrine conditions is crucial for effective management.
  • Further research into diabetic bone disease and the immunological effects of pregnancy on autoimmune conditions is warranted.