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Azelaic acid has antimycotic properties in vitro
1Department of Dermatology, University of Kiel, FRG.
Dermatology (Basel, Switzerland)
|January 1, 1993
Summary
Azelaic acid demonstrates antimycotic properties, effectively suppressing common fungal growth like dermatophytes and Pityrosporum ovale at specific concentrations. Further in vivo studies are recommended to explore its potential as an antifungal treatment.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Azelaic acid is recognized for its antibacterial properties.
- Its potential as an antimycotic agent remains largely unexplored.
- Systematic investigation into azelaic acid's antifungal effects is warranted.
Purpose of the Study:
- To systematically evaluate the inhibitory effects of azelaic acid on various fungi.
- To determine the effective concentrations of azelaic acid against specific fungal species.
- To assess the influence of pH on the antimycotic activity of azelaic acid.
Main Methods:
- Agar dilution technique was employed to assess fungal growth inhibition.
- Tested fungal species included common dermatophytes, Scopulariopsis brevicaulis, Candida albicans, Candida glabrata, and Pityrosporum ovale.
- Evaluated azelaic acid's efficacy at different concentrations and pH levels.
Main Results:
- Azelaic acid (0.56%) inhibited dermatophytes and S. brevicaulis.
- Pityrosporum ovale was suppressed by 1% azelaic acid.
- Complete inhibition of Candida glabrata was observed at 4% azelaic acid, while Candida albicans showed partial growth.
- Antimycotic activity was noted between pH 4.8-5.5; the disodium salt was ineffective at pH 6.1.
Conclusions:
- Azelaic acid exhibits significant antimycotic activity against a range of fungi.
- The efficacy of azelaic acid is pH-dependent.
- Results suggest azelaic acid warrants further investigation for in vivo antifungal applications.