Effect of nickel sulphate on male rats

Cytopathological and histopathological changes in skin, liver, kidney and testis of rats due to nickel sulphate have been studied experimentally. Skin of nickel sulphate painted rats showed hyperkeratinization, vacuolization, hydropic degeneration of basal layer and atrophy of epidermis. The testis showed degeneration and oedema of seminiferous tubules, while liver showed areas of focal necrosis, congestion and dilatation of sinusoids.