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Epocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological
Y Nihei1, H Yamamoto, M Hasegawa
1Bristol-Myers Squibb Research Institute, Tokyo, Japan.
The Journal of Antibiotics
|January 1, 1993
Abstract:
New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carbazole antibiotics having a novel substitution pattern and an epoxide in the side chain.