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Extensive cutaneous hyperpigmentation caused by minocycline

M Pepine1, F P Flowers, F A Ramos-Caro

  • 1Department of Medicine, University of Florida College of Medicine, Gainesville.

Journal of the American Academy of Dermatology
|February 1, 1993
PubMed
Summary
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Minocycline can cause extensive skin hyperpigmentation due to lysosomal iron deposition. Discontinuing the antibiotic allows for gradual skin color normalization over several years.

Area of Science:

  • Dermatology
  • Toxicology
  • Internal Medicine

Background:

  • Cutaneous hyperpigmentation can be a challenging diagnostic presentation.
  • Differential diagnoses include hemochromatosis and heavy metal deposition.

Observation:

  • A 65-year-old male presented with extensive cutaneous hyperpigmentation over 2.5 years.
  • Affected areas included sclerae and nail beds, sparing palms and buttocks.

Findings:

  • Histologic and electron microscopy confirmed lysosomal iron deposition.
  • Patient history revealed minocycline use as the causative agent.

Implications:

  • Minocycline-induced hyperpigmentation is a distinct clinical entity.
  • Discontinuation of minocycline leads to gradual resolution of skin discoloration.

Related Experiment Videos

  • This case highlights the importance of thorough medication history in diagnosing pigmentary changes.