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Nonfamilial diffuse palmoplantar keratoderma associated with bronchial carcinoma
S K Khanna1, F A Agnone, A I Leibowitz
1Department of Radiologic Sciences, UCLA School of Medicine.
Journal of the American Academy of Dermatology
|February 1, 1993
Summary
A case study links lung cancer (epidermoid carcinoma) to thickened skin on the palms and soles (palmoplantar hyperkeratosis). This highlights a potential connection between internal cancers and skin conditions.
Area of Science:
- Oncology
- Dermatology
- Internal Medicine
Background:
- Palmoplantar hyperkeratosis is a group of skin conditions causing thickened palms and soles.
- Various factors can cause palmoplantar hyperkeratosis, including genetic and environmental influences.
Observation:
- A 61-year-old woman with lung epidermoid carcinoma presented with new-onset diffuse hyperkeratosis of palms and soles.
- This clinical presentation suggested a potential link between the internal malignancy and the observed skin changes.
Findings:
- The case indicates a possible association between epidermoid carcinoma of the lung and palmoplantar hyperkeratosis.
- This association warrants further investigation into paraneoplastic dermatologic manifestations.
Implications:
- Recognizing palmoplantar hyperkeratosis may aid in early detection of internal malignancies.
- Further research is needed to understand the mechanisms underlying cancer-associated keratodermas.