Stimulating new developments. Colony-stimulating factors

Drug-induced low white-blood-cell counts have long impaired our ability to treat patients. Colony-stimulating factors are now available for intravenous or subcutaneous administration. These glycoproteins act on hematopoietic cells by binding to specific cell surface receptors and by stimulating proliferation, differentiation, commitment, and activation of new white blood cells. A brief overview of patient population, indications, actions, and adverse reactions for hospital or home use is presented.