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[Cardiocirculatory side effects of hyperthermic extremity perfusion]
1Abteilung für Allgemein-, Abdominal- und Gefässchirurgie, Universität des Saarlandes, Homburg/Saar.
Langenbecks Archiv Fur Chirurgie
|January 1, 1993
Summary
Hyperthermal limb perfusion for melanoma may increase pulmonary vascular resistance and cause blood circulation issues. Monitoring pulmonary arterial pressure is crucial, especially for patients with vascular occlusive disease.
Area of Science:
- Oncology
- Cardiovascular Science
- Pharmacology
Context:
- Investigating cardiocirculatory risks associated with hyperthermal limb perfusion in high-risk melanoma patients.
- Assessing complications in patients with vascular occlusive diseases undergoing extracorporeal circulation.
Purpose:
- To evaluate the incidence of cardiocirculatory disorders post-hyperthermal limb perfusion.
- To identify the causes of increased pulmonary vascular resistance and blood pressure abnormalities.
Summary:
- Hyperthermal limb perfusion for melanoma treatment led to increased pulmonary vascular resistance postoperatively.
- Patients with vascular occlusive disease experienced increased extracorporeal circulation leakage.
- Elevated thromboxane and prostacyclin levels were observed due to blood trauma in the heart-lung machine.
- Cisplatin levels in systemic circulation remained insignificant.
- Pulmonary and arterial pressure disorders were noted in patients with occlusive vascular diseases.
Impact:
- Highlights the necessity of monitoring pulmonary arterial pressure during isolated limb perfusion.
- Suggests potential risks associated with extracorporeal circulation and blood manipulation.
- Provides insights into managing oncological treatments with cardiovascular considerations.