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Related Experiment Videos

[Axillary recurrence after lymph node excision in malignant melanoma]

L Kretschmer1, C Lautenschläger, K P Preusser

  • 1Hautklinik, Martin-Luther-Universität Halle-Wittenberg.

Langenbecks Archiv Fur Chirurgie
|January 1, 1993
PubMed
Summary

Axillary lymphadenectomy recurrence is common in stage II, with regional metastases being a key predictor. Early detection and management are crucial for improving survival rates in advanced cancer stages.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Clinical Research

Context:

  • Retrospective analysis of 143 patients undergoing 155 axillary lymphadenectomies.
  • Patients categorized into Stage I (negative nodes), Stage II (node metastases), and Stage III (node and distant metastases).
  • Maximum follow-up of 8 years (mean 51.9 months).

Purpose:

  • To evaluate the incidence and prognostic factors of axillary recurrence after lymphadenectomy.
  • To assess the impact of recurrence on patient survival.
  • To identify predictors for recurrence in different stages of axillary lymph node involvement.

Summary:

  • Five-year survival rates were 77.5% for Stage I and 28.6% for Stage II.
  • Axillary recurrence occurred in 30.7% of Stage II patients, exclusively within 20 months post-surgery.

Related Experiment Videos

  • Regional in-transit cutaneous metastases were the sole significant predictor (p=0.048) of recurrence in Stage II; other factors like tumor characteristics and adjuvant chemotherapy did not show significance.

    • Impact:

    • Regional in-transit cutaneous metastases are a critical indicator for axillary recurrence risk in Stage II disease.
    • Median survival post-recurrence (5 months) is poor and comparable to Stage III lymphadenectomy survival (7 months).
    • High incidence (>30%) of regional metastases observed in both recurrent and Stage III groups, highlighting treatment challenges.