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Omeprazole: a comprehensive review
F Massoomi1, J Savage, C J Destache
1Clinical Pharmacokinetic Service and Laboratory, Creighton University School of Pharmacy, Omaha, NE 68178.
Pharmacotherapy
|January 1, 1993
Summary
Omeprazole, a proton pump inhibitor, effectively treats acid-related disorders like ulcers and reflux. It offers rapid healing and convenient dosing, showing superiority in managing Zollinger-Ellison syndrome.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Omeprazole represents a novel class of substituted benzimidazoles.
- These agents target the gastric parietal cell's proton pump, inhibiting acid secretion.
Purpose of the Study:
- To investigate omeprazole's efficacy in treating gastric ulcers, duodenal ulcers, gastroesophageal reflux, and hypersecretory conditions.
- To evaluate omeprazole's dosing convenience and comparative effectiveness against existing therapies.
Main Methods:
- Clinical investigation of omeprazole for various acid-related gastrointestinal disorders.
- Comparative analysis of omeprazole's healing rates and tolerability versus conventional treatments.
Main Results:
- Omeprazole allows for convenient once-daily or twice-daily dosing for conditions like peptic ulcer disease and Zollinger-Ellison syndrome.
- Demonstrates a more rapid ulcer healing rate and is well-tolerated compared to current therapies.
- Shows superiority in treating Zollinger-Ellison syndrome.
Conclusions:
- Omeprazole is an effective and well-tolerated treatment for acid-related gastrointestinal disorders.
- Its prolonged acid inhibition facilitates simplified dosing regimens.
- Offers improved outcomes, particularly for severe hypersecretory conditions.