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Sinus arrest associated with continuous-infusion cimetidine
D T Hulisz1, J R Welko, D E Heiselman
1Department of Pharmacy and Internal Medicine, Akron General Medical Center, OH 44307.
Pharmacotherapy
|January 1, 1993
Abstract:
The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous-infusion cimetidine.