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Related Experiment Videos

Sinus arrest associated with continuous-infusion cimetidine

D T Hulisz1, J R Welko, D E Heiselman

  • 1Department of Pharmacy and Internal Medicine, Akron General Medical Center, OH 44307.

Pharmacotherapy
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Continuous-infusion cimetidine can cause sinus arrest, a rare heart rhythm issue. This case highlights a potential risk with this specific cimetidine administration method.

Area of Science:

  • Pharmacology
  • Cardiology
  • Oncology

Background:

  • Cimetidine is a histamine H2 receptor antagonist used to reduce stomach acid.
  • Bradyarrhythmias, including sinus arrest, are rare but known side effects of intermittent cimetidine infusions.

Observation:

  • A patient with leukemia receiving continuous-infusion cimetidine developed recurrent sinus arrest.
  • The cardiac events were directly linked to cimetidine administration and resolved upon its discontinuation.

Findings:

  • This report details the first instance of sinus arrest associated with continuous-infusion cimetidine.
  • The patient's condition did not recur after switching to ranitidine, suggesting cimetidine as the cause.

Implications:

Related Experiment Videos

  • Continuous-infusion cimetidine may pose a risk for sinus arrest, particularly in vulnerable patients.
  • Clinicians should consider this potential adverse effect when prescribing continuous cimetidine infusions.
  • Further investigation into the mechanism of cimetidine-induced sinus arrest is warranted.