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Related Experiment Videos

Relation between patent foramen ovale and unexplained stroke

G Van Camp1, D Schulze, B Cosyns

  • 1Department of Cardiology, Saint-Pierre University Hospital, Bruxelles, Belgium.

The American Journal of Cardiology
|March 1, 1993
PubMed
Summary

Patent foramen ovale (PFO) may contribute to cryptogenic stroke. Early, massive contrast passage into the left atrium during echocardiography, coupled with abnormal PFO morphology, indicates a higher stroke risk.

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Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Patent foramen ovale (PFO) is a potential, yet debated, cause of cryptogenic stroke.
  • Understanding PFO characteristics is crucial for stroke risk stratification.

Purpose of the Study:

  • To investigate the relationship between PFO characteristics and unexplained stroke incidence.
  • To identify specific PFO features associated with cerebrovascular accidents.

Main Methods:

  • Comparative analysis of 29 patients with unexplained stroke and 28 controls.
  • Echocardiographic assessment of PFO: timing and magnitude of left atrial contrast, and atrial septum morphology.

Main Results:

  • A significant association was found between stroke incidence and early, massive contrast passage in the left atrium (21% vs 0%, p < 0.05).

Related Experiment Videos

  • Abnormal foramen ovale morphology was more prevalent in patients with PFO (69% vs 2%, p < 0.001).

    • Conclusions:

    • Early and massive contrast passage via PFO, especially with abnormal morphology, suggests a role in cryptogenic stroke.
    • Contrast transesophageal echocardiography timing and quantification are valuable for assessing stroke risk in PFO patients.