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Collagenous colitis: are bacterial cytotoxins responsible?
T Andersen1, J R Andersen, M Tvede
1Department of Internal Medicine F, Gentofte County Hospital, Denmark.
The American Journal of Gastroenterology
|March 1, 1993
Abstract:
In a case of collagenous colitis, cholestyramine treatment resulted in symptomatic and histological normalization. After discontinuation of cholestyramine, collagenous colitis relapsed. At this time fecal cytotoxic activity was demonstrated in McCoy cell lines. Symptoms, histologic changes, and cytotoxicity disappeared when cholestyramine treatment was reinstituted. We hypothesize that a bacterial toxin is responsible for the development of collagenous colitis.