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Urinary endothelin-1: not a useful marker for preeclampsia
J R Barton1, B M Sibai, W D Whybrew
1Department of Obstetrics and Gynecology, University of Tennessee, Memphis.
American Journal of Obstetrics and Gynecology
|February 1, 1993
Summary
Urinary endothelin-1 levels did not differ between pregnant individuals with and without preeclampsia. This suggests urinary endothelin-1 is not a reliable biomarker for diagnosing preeclampsia.
Area of Science:
- Obstetrics and Gynecology
- Renal Physiology
- Cardiovascular Physiology
Background:
- Preeclampsia is a serious pregnancy complication.
- Endothelin-1 (ET-1) is a potent vasoconstrictor implicated in hypertension.
- Urinary ET-1 may reflect systemic ET-1 activity.
Purpose of the Study:
- To investigate urinary endothelin-1 levels in preeclampsia.
- To determine if urinary ET-1 is a useful biomarker for preeclampsia.
Main Methods:
- Assayed urinary endothelin-1 (ET-1) levels.
- Compared levels between 50 gravidas with preeclampsia and 11 with normotension.
- Measured levels in the third trimester of pregnancy.
- Expressed results as fmol/mg urinary creatinine.
Main Results:
- Mean urinary ET-1 levels were 79.8 +/- 9.3 fmol/mg creatinine in preeclampsia.
- Mean urinary ET-1 levels were 62.7 +/- 7.5 fmol/mg creatinine in normotensive controls.
- No significant difference in urinary ET-1 levels was observed between the groups.
Conclusions:
- Urinary endothelin-1 excretion is not significantly elevated in preeclampsia.
- Urinary endothelin-1 is unlikely to be a valuable diagnostic marker for preeclampsia.