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Intermittent sinusoidal heart rate pattern in vagotomized fetal lambs
Y Ninomiya1, P C McMahan, Y Murata
1Department of Obstetrics and Gynecology, University of California, Irvine, Orange 92613-1491.
American Journal of Obstetrics and Gynecology
|February 1, 1993
Summary
Arginine vasopressin dose influences fetal heart rate patterns, with intermittent sinusoidal heart rate more common at lower doses. Fetal sleep cycles also affect sinusoidal heart rate occurrence, favoring non-rapid-eye-movement sleep.
Area of Science:
- Perinatal physiology
- Fetal monitoring
Background:
- Fetal heart rate patterns can indicate fetal well-being.
- Arginine vasopressin plays a role in fetal cardiovascular regulation.
Purpose of the Study:
- To examine the link between arginine vasopressin dosage and fetal heart rate patterns.
- To investigate the relationship between intermittent sinusoidal heart rate and fetal sleep states.
Main Methods:
- Induction of sinusoidal heart rate patterns in fetal lambs via arginine vasopressin infusion.
- Monitoring of fetal heart rate, tracheal pressure, and electrooculogram.
- Analysis of sinusoidal heart rate frequency and pattern in relation to drug dosage and sleep cycles.
Main Results:
- Intermittent sinusoidal heart rate was observed across various arginine vasopressin doses, with higher incidence at lower doses.
- Sinusoidal heart rate patterns were more frequent during non-rapid-eye-movement sleep compared to rapid-eye-movement sleep.
- A dose-dependent relationship was noted for arginine vasopressin-induced sinusoidal heart rate.
Conclusions:
- Arginine vasopressin dosage is a significant factor in the development of sinusoidal fetal heart rate.
- Fetal sleep state influences the occurrence of sinusoidal heart rate, with a preference for non-rapid-eye-movement sleep.
- The findings support the hypothesis that persistent sinusoidal heart rate may indicate fetal stress.